Monday, September 30, 2019
It320 Hmwk 4.1
Wan Technology/ Unit 4 Assignment: 4. 1 1. At what layer of the OSI model does CDP operate? Data Link layer 2. What is the primary use for CDP? To discover information about directly connected Cisco devices 3. What network layer protocols can CDP provide information for? IP, Internetwork Packet Exchange (IPX), and AppleTalk 4. When CDP is enabled on an interface, a router (or switch) sends CDP advertisements on a regular basis, which list information about the sending router. Included in the packets are a series of Type/Length/Value, or TLV, data structures. . The show cdp neighbors command can be used to display one line of information about each directly connected CDP-enabled device. List the six pieces of information displayed. Device ID, local interface, holdtime, capability, platform, and port ID 6. In the topology of all Cisco devices shown in Figure 4-1, you are on Host A and consoled in to RTA. What devices can you see in the output from CDP commands? SWA, RTB, and RTC only the directly connected devices that are attached to RTA 7. How would you gather information about other CDP-enabled devices in the network?By Telneting to those devices and using the show cdp neighbors command 8. From RTB in Figure 4-1, what devices can you see in the output from CDP commands? RTA and RTD 9. From RTC in Figure 4-1, what devices can you see in the output from CDP commands? RTA and RTD 10. From RTD in Figure 4-1, what devices can you see in the output from CDP commands? RTB, RTC, and SWB 11. cdp run Global Enables CDP globally on the router. cdp enable Interface Enables CDP on an interface. lear cdp counters Privileged EXEC mode Resets the traffic counters to 0. show cdp entry User or privileged EXEC mode Displays information about a specific neighbor. show cdp interface User or privileged EXEC mode Displays information about interfaces on which CDP is enabled. show cdp neighbors [detail] User or privileged EXEC mode Displays at least six pieces of information a bout the neighbor 12. The cdp run command enables CDP globally on the router. By default, CDP is globally enabled. The enable cdp command enables CDP on a particular interface. 13.Fill in the appropriate commands in the configuration/output that follows: RTC(config)#cdp run_ <– Command that will start CDP RTC(config)#interface Ethernet 0 RTC(config-if)#no cdp enable <– Turn off CDP on this interface RTC(config-if)
Sunday, September 29, 2019
Kris Corporation Information Technology Proposal Essay
Kris Corporation Information Technology Proposal Introduction Information Technology Proposal            Kris Corporation is a prominent company that deal with manufacturing parts utilized by the automotive industry. The organization’s Active-Domain infrastructure comprises of two main domains. The parent domain is kris.local and the child domain is corp.kris.local. The AD infrastructure of the organization is running on Server 2008. The company has five branches located in five cities namely, Chicago (IL), Baltimore (MD), Atlanta (GA), Seattle (WA) and San Diego (CA). Its manufacturing plants are located in Seattle and Atlanta.            Recently, the company has developed a number of concerns relating to its information system. First, the corporation is concerned about adopting multiple domains in its information systems. Secondly, some automobile manufacturing companies have approached the corporation and requested it to use a single identity in the process of procuring orders. Kris Corporation is also concerned with disaster recovery of its systems and physical space of servers especially at the Atlanta branch since it is the corporation’s headquarter. File sharing is also a big concern to the company since the locations are connected to the internet independently.            This proposal focuses on identifying and analyzing various changes in the information technology department of the company and developing solution recommendations for information technology problems experienced by the company. The proposal will discuss various benefits the corporation will acquire from updating and changing the current information systems to the modern systems. Active Directory            Kris Corporation should adopt the new Windows Server 2012 in its information systems due to the following reasons. First, the server has the freedom to choose the interface. This means that by installing the Server Core it will prove security and performance advantage. In addition, it has a feature that allows one to switch it on or off. Secondly, the server manager is a multi-server making it easy to deploy features and roles to physical and virtual server. It also makes easy to merge servers that can be managed together hence, easing the administration of servers (Snover, 2012).            Thirdly, Windows Server 2012 provides a Dynamic Access Control (DAC) which helps to create more centralized security models for access to the network. This is done by tagging the sensitive data both, manually and automatically on the basis of creator of the files and the content of the files. In addition, Windows Server 2012 have a large storage spaces, a new feature that allow the usage of inexpensive hard drives to create a storage which can be subdivided into spaces as those used on physical disk.            Window Server 2012 also possesses Hyper –V Replica administrator which replicates their Hyper- Virtual machine from Hyper –v host at a primary site to another Hyper-V host at the replica site. This feature has the advantage of lowering the cost of ownership in an organization by providing workload –agonistic and storage- agonistic solution which replicates effectively, efficiently and periodically over IP-based network within or across different storage subsystems and across all sites. The major benefit of Hyper-V Replica is that virtual machine can easily replicate in distinct locations for higher protection and to ensure availability. Window server 2012 also possesses Direct Access, which works with IPv4 that do not require conversion of technologies and switching off the server that are running. Direct access version of 2012 server is easier to configure too.            The window server 2012 has Remote Desktop Service that provides the ability to control and centralize the applications and data that the employees need t work on from variety of machines or devices making it easy to work anywhere as long as you access a device. It also supports that control and compliance are met strictly. Lastly windows server 2012 has a simplified licensing. Microsoft have worked on the complexity involves in finding the right edition and cost. Window server 2012 has only four editions; datacenter standard essential and the foundation. These editions are licensed as per number of user for the instance foundation is licensed for 15 while essential 25. Adoption and acquiring of the server depends on the size of the company and then moving ahead buying the right edition. For the case of the Kris Company, the ideal edition is Window Server 2012 R2 Essential which is the best for cloud-connected first server.            The Domain model that a company uses determine its effectiveness and affects its performance. In the selection of the appropriate domain model to use, the company should consider a number of factors that may affect the selected Domain model. First, the company must consider the amount of the capacity available on the network allocated to Active Directory Domain service. The company should choose a model with maximum efficiency in replicating information with mild effects on the network bandwidth. Secondly, the company must consider the number of users. A company should use more than one domain where the number of users is large.            The corporation should migrate to a single domain and abandon the multi-domain model. The single domain is the simplest domain design that a company can use effectively. Unlike in other domain designs, there is replication of all information to all domain controllers. Secondly, single domain design minimizes the number of deployed domains in the forest. Minimizing the number of domains reduces the complexity of the application. Consequently, the total cost of ownership is reduced. Any domain controller in the single domain model can effectively authenticate a domain user in the forest. In the single domain model, all domain controllers in a company’s system can be developed to be global catalogs. This will enable the corporation to use the single identity in order procurement processes from automobile manufacturers. Lastly, the corporation should deploy the single domain model since all data can be replicated to all its geographical locations hosting domain controllers (Windows Server, 2015).            Single sign-on is a part of the modern technology where users use locally logged on credentials when connecting to hosted desktops and Remote Apps. The technology that provides the single sign-on is Windows Server 2012. Windows Server 2012 enables users to log in without using multiple certificates and without any prompts in credentials. It is much easier to configure single sign-on (SSO) into the Windows Server 2012 than in other servers. The administrator needs to enter the qualified domain name with a prefix â€Å"TERMSRV†to the server data of the Credentials Delegation Group Policy setting. The Single Sign-On can also be configured by adding the Remote Desktop Gateway (RD Gateway). Thirdly, the Single Sign-On can be configured using the command line. Click â€Å"Start†, then click â€Å"Run†and type â€Å"cmd†. Open the Enterprise Single Sign-On directory for installation and type â€Å"ssomanage-enabless o†to enable the SSO (Termserv, 2012). DNS            A DNS server is any computer that is allowed to join the DNS. The server is responsible for running a special purpose networking software. The DNS server should reside in Seattle. Although Atlanta is the corporation’s headquarter, the location has limited space and a large number of staffs. The corporation should ensure that the DNS server reside in Seattle where there is adequate space. Secondly, there are manufacturing plants in Seattle thus it is appropriate to set up the DNS server. The IT staff should be relocated to Seattle for effective management of DNS server and IT systems.            DNS is one of the important components in any networking system. Therefore, it is important to secure the DNS from attackers and other risks. There are a number of risks that may attack the DNS. These include DNS cache poisoning, distributed denial of service (DDoS), denial of service, reflected attacks, fast flux and reflective amplification DoS. There are various DNS security techniques and procedure that are used to protect the DNS servers. First, a latest and updated DNS server and software versions should be used. For instance, Windows Server 2012 provides more DNS protection than other servers. The Windows Server 2012 prevents attacks using security loopholes. Secondly, a freeware such as ZoneCheck can be used to check the configuration and monitor external networks. Deploying a DNS security (DNSSEC) protocol based is also a viable solution to DNS security. A DNSSEC reduces the risk of DNS cache poisoning and other DNS attacks. DHCP            Dynamic Host configuration Protocol (DHCP) is a server or client protocol that automatically provides an internet protocol host with IP address. The purpose of using DHCP in window server 2012 is that it reduces the administrative tasks and the configuring the host network complexity such as, private intranet. DHCP automates the process of configuring the IP and TCP of the client.            DHCP offer support on DNS registration enhancements. This means that one can use HDCP policies to configure conditions on qualified domain name of DHCP client and also register workgroup computer as a guest DNS suffix. DHCP also support PowerShell DHCP server which is the task oriented for DHCP server management. Window PowerShell uses object pipelining to ease the need for parsing and alteration of test output. This window PowerShell for DHCP has got 103 cmdlets which cover multiple aspects of DHCP server configuration and management.            Another role of DHCP is to introduce a new policy based on IP address assignment feature. This allows the administrator to group DHCP client by specific tasks on fields and boost the administrator control over configuration parameters brought forth to the network device. DHCP policy enables flexibility while dealing with multiple device types, multiple roles, and virtualization. Consequently, it is important to Kris Company to consider DHCP for management of various task and device for easier access and to avoid duplication of tasks hence, lower cost of administration.            The tracking of DHCP is done using IPAM (IP Address Management) that enable IP tracking through correlation of DHCP lease happenings on managed DHCP servers with user and computer authentication happening or events on managed domain controller. The IP address tracking by use of IPAM occur using the following parameters; tracking by IP address (IPV4), tracking by hostname, tracking by username, and tracking by client ID (TechNet, 2015). Hyper-V.            Hyper- V is an interesting feature in Windows servers. Consultants and system integrators say that hyper-v is a promising and effective virtualization platform. The features have both advantages and disadvantages. Hyper-V is an incorporative and important feature to clients using the Windows Server 2008 or 2012. Clients save on licensing costs while using hyper- v rather than other virtualization platforms. Secondly, Microsoft provides better support for the server application running on Hyper-V as opposed to other virtualization platforms. Hyper- V provides an option of consolidating multiple physical servers into comparatively fewer servers. Machines running the Hyper-V platforms are more effective and faster as compared to machines running other virtualization platforms. Therefore, Hyper- V is effective and fast.            Hyper – V improves utilization and access to key resources such as networking, disk, and video when running guest operation systems. It is easier to deploy and manage the Hyper-V application than other virtualization platforms. However, the application is only limited to only 64 bit systems using the Windows Servers. Therefore, users with other systems such as Linux cannot use it. Secondly, the platform may be compatible with some devices using Windows Servers 2008, and others may not be incompatible. Therefore, a test for compatibility is necessary to devices. Hyper- V does not require clustering because it is a cluster aware application, and Windows Server 2008 provides a host clustering support for Hyper – V virtualized made machines.            Kris Corporation can leverage various features of Hyper-V. First, Hyper-V has Access Control through authorization manager that will enable the corporation to create custom roles to allocate or delegate activities within Hyper- V. The corporation will also benefit from improved VM performance provided Hyper-V. The application also has guest OS support where it supports both 64-bit and 32-bit virtual machines operating on different operating systems. Large number of users in the corporation can utilize the application since it supports a large number of users. The application provides support for virtual networking for systems in different locations thus enabling users within the corporation to communicate easily. Security            The Kris Corporation can improve its networking by practicing transparent caching on the client computer for shared folder and reducing the duration required for accessing files. This involves protocol enhancement that do away with multiple and redundant network operations when saving or opening folders. Secondly, the corporation should carry out background synchronization capabilities for offline file, reduce management overhead and supporting the end-user experience (Windows, 2015).            In conclusion, the Kris Corporation should migrate to 2012 AD since the server provides better services to its activities than the Windows Server 2008. The 2012 AD is faster, safer and incorporates more systems than the 2008 AD. The corporation should also migrate to the single domain. The single domain enables users in different geographic locations to receive the same information and be connected with each other. Single domain will enable the corporation to have a single identity in procuring orders from automotive manufacturing companies. The single sign-on can be effectively provided by the Windows Server 2012.            The DNS server of should reside in Seattle because it has adequate space and a manufacturing plant is located in Seattle. The IT staff located in Atlanta should be relocated to Seattle to effective manage the DNS server and manage the corporation’s IT systems. These staffs will also allow other staff to work effectively in Atlanta. The DHCP fault tolerance in the corporation will be implemented to improve tracking of IP address automatically. The DHCP addresses can be tracked by username, ID, and IP. Implanting Hyper-V will enable the Kris Corporation to have effective virtual connectivity among users in different locations. Lastly, the corporation can improve networking capabilities of security and file sharing through transparent caching and reducing time. References Snover J. (2012). Windows Server 2012 Remote Desktop Services (RDS). Window Server Blog. Retrieved from http://blogs.technet.com/b/windowsserver/archive/2012/05/09/windows-server-2012-remote-desktop-services-rds.aspxWindows Server (2015). Reviewing the Domain Models. Retrieved from https://technet.microsoft.com/en-us/library/cc731718%28v=ws.10%29.aspxDeuby S. (2013). 7 More Reasons to Upgrade to Windows Server 2012 Active Directory. Windows IT Pro. Retrieved from http://windowsitpro.com/identity-management/7-more-reasons-upgrade-windows-server-2012-active-directoryTermserv (2012). Remote Desktop Web Access single sign-on now easier to enable in Windows Server 2012. Remote Desktop Services Blog. Retrieved from http://blogs.msdn.com/b/rds/archive/2012/06/25/remote-desktop-web-access-single-sign-on-now-easier-to-enable-in-windows-server-2012.aspxTechNet (2015). IP Address Tracking. Retrieved from https://technet.microsoft.com/en-us/library/jj878332.aspxWindows (2015). File Sharing and O ffline Files Enhancements. Retrieved from https://technet.microsoft.com/en-us/library/dd637828%28v=ws.10%29.aspx Source document
Saturday, September 28, 2019
Minimum Efficient Scale Essay Example | Topics and Well Written Essays - 1250 words
Minimum Efficient Scale - Essay Example The MES is hardly ever a solitary output - more likely it is a range of production levels where standard cost is minimized where the firm achieves regular returns to scale. It varies from industry to industry depending on the type of the cost structure in a particular segment of the market. When the proportion of fixed to variable costs is very elevated, there is huge potential for dropping the average cost of production. The minimum efficient scale may be expressed as a variety of production standards, but its connection with the whole market size or demand will conclude how many competitors can successfully function in the market. If the minimum efficient scale is comparatively diminutive compared to total market size many companies can survive in the same space for example computer software companies. In other industries where the minimum efficient scale is quite large due to high fixed costs, only a few major players dominate the market place for example telecom and other basic materials. There is also likely to be enormous potential to take advantage of technical economies of scale. As a consequence the MES may be a high quantity of entire market demand. There may be an opportunity merely for single business to completely exploit the economies of scale obtainable in the industry. It is presumed for a natural monopoly that the long-run average cost curve falls constantly over a very great range of output. This is illustrated in the diagram below. Companies are able to exploit the market when the range of their minimum efficiency scale is high as this applies a barrier to entry. The higher the barriers to entry, the greater the ability of established firms to raise price above the long run average costs without letting the new firms enter the market this includes foreign competition too. Although production cost barriers are faced by both local and foreign companies, the foreigners face an additional barrier of tariffs levied by the government. As the manufacturers expand their scale of production, average costs decrease to minimum efficient scale that is to the optimal point. As they expand further than that, they become incompetently large, and face increasing average costs. Hence if we assume they increased too far, and finally settled at the minimum efficient scales they have oppressed all Economies of Scale, and Diseconomies of Scale, in manufacturing. Big firms can have lesser per-unit costs due to purchasing at bulk discounts example parts, indemnity, real estate, marketing, etc. and can also bound competition by buying out competitors, setting proprietary industry values. Looking at further examples, an automobile maker can buy millions of tons of steel at one point for use in forming engine blocks and store it for an indefinite period, if this will get a superior price. On the other hand, a florist can't buy millions of tons of matured flowers to put up for sale as they will shrivel before they are sold. This results in disparate interpretations of economies of scales for diverse types of companies. The size of a business may also alter over time, as industry and marketplace circumstances change. If a dealer finds a way to produce
Friday, September 27, 2019
Relationship Literacy Article Essay Example | Topics and Well Written Essays - 1000 words
Relationship Literacy Article - Essay Example Fundamentally speaking, most forms of abuse originate for the abuser, as a learned behavior. In fact, most abusers were in fact abused themselves as children in the case of either sexual, physical or emotional abuse. When this type of behavior is exhibited to children and youth as a ‘normal’ means of interacting, the individual then proceeds into their future social interactions with the ideology that abusive behavior is not only acceptable but also normal. By implementing relationship literacy on an early childhood educational level and on through the adolescent years, individuals will be more readily equipped with the social and moral tools to properly interact with others throughout their life. This is a two fold process. By teaching and modeling proper human interaction within the school system, children will certainly have a comprehensive understanding of what is socially expected of them as a member of society. Furthermore, the rule of no tolerance towards school v iolence, verbal threats and abuse and sexual forms of abuse; will further instill within children a sense of accountability and consequence. The question of where to begin the approach to relationship literacy training can be answered by approaching the topic where it is most needed. In fact, the origin of the program began in inner city environments, ten years ago, with an approach to anger management as well as an emphasis on the overall importance of personal relationships and healthy social interaction. In so many cases, violence and abuse prevail simply because so many are not equipped with proper mechanisms of dealing with anger and conflict. By placing emphasis on virtues such as sympathy and apathy, programs offering relationship literacy training can prepare children and youth for future appropriate and healthy relationship interaction. With the growing need to address national
Thursday, September 26, 2019
GDP in China Essay Example | Topics and Well Written Essays - 750 words
GDP in China - Essay Example The national government of China too had acted out in a similar way to prove its worth over time, as the present discussion would reveal. Economic Growth of China The graphical depiction underneath is indicative of the economic fluctuations that the nation underwent during the last 10 years. It clearly shows how the nation had gone through fluctuations over time even though it had maintained a continued upward stride. However, the growth rate of GDP dipped down to its lowest during 2009-10, primarily due to the global financial shock which had hindered economic activities in many parts of the world. The primary cause behind China’s fast increase in growth rate had been its foreign trade policy of maintaining a positive current account balance. In other words, the nation complied to the export led growth strategy which is why it managed to accumulate a large volume of foreign exchange reserves. This factor alone led to a gradual appreciation in the rate of exchange of Renminbi against US dollars. The economic fluctuations which the nation underwent over time had hence, been basically the result of economic shocks arising in foreign nations, or to be precise, the Western economies which count for the highest demand for Chinese goods. Remedial measures and consequences GDP growth in China dipped down to its lowest between 2009 and 2010, when the Western economies had been the affected badly by the financial crisis. The prime reason behind this had been the high dependence of China upon its export revenues derived from the US and European economies. However, the national government of China soon framed policies which could recoup the nation from the looming crisis. The administration injected a sum of Renminbi 4 trillion within the nation in order to bail its various sectors out of the crisis. This infusion actually helped the nation’s industrial production to gain momentum once again and so did the rate of profit of the manufacturers. Furthermore, th e national government also decided to raise its total investment in fixed assets; to be precise, the growth in fixed asset investment during the first half of 2009 rose by 7.2 percentage points as against that exactly a year before. The government also took measures to accelerate the aggregate domestic demand in order to save the indigenous industrial houses. The sale of consumer products in the nation reached the level of 5,871.1 billion Yuan, which is found to be a growth of 16.6 percent after adjustment for price factors. However, though the national government framed policies to save the domestic economic environment, it had no hold over foreign operations, which is why it could not get over its deflating current account position. This resulted to a depleting foreign reserve position and thus, a depreciating rate of exchange. But, irrespective of its trade position, both the rural and urban populations of the nation experienced a slight increase in their per capita levels of inc ome. Moreover, the national government’s objective had been to bail out the nation out of any hints of recession. Thus, it implemented ways through which the flow of money within the nation could be maintained. The financial houses within the nation thus, invented ways to instigate people towards demanding more loans so as to keep the velocity of money within the nation high. The higher the money supply in an economy, higher will be the domestic
Communication in the Nursing Profession Essay Example | Topics and Well Written Essays - 2000 words
Communication in the Nursing Profession - Essay Example Communication may be verbal, non-verbal, or inferred through the actions that a nurse may take or avoid. Communication may be a single sentence that begins with the sender, but the receiver is the integral part of the process where the message is interpreted and placed in context with a larger discourse. Communication is ubiquitous and pervasive. Every bit of information that is transferred from nurses to the world around them comes through some form of communication. In today's fast paced world of nursing, where accuracy and time can make the difference between success and failure, communication becomes the most critical component driving a patient's outcome. The structure of a health care setting today is far more inter-dependent than at any other time in history. Cultural and social diversity have made the communications between nurses and patients at risk of miscommunication, but has also presented nurses with the opportunity to be more articulated and meaningful. Communication skills are an area where it is sometimes difficult to measure, yet there are always issues that warrant improvement. In addition, knowledge is passed from nurses, specialists, and physicians through the act of communicating. It is one of the single most important activities that a health care worker engages in. Technology has presented nurses with new opportunities and methods of communication, though there is always some resistance to change within any group. This paper will evaluate some of the current literature in regards to communications among the nursing profession. By knowing what technologies are available, the current thinking on communication, and th e impact of culture and diversity, nurses can elevate the status of their communications and get more value for the time that they spend communicating Literature Review. Bedside Manner Some of the most prevalent and important communications for a nurse takes place between the nurse and the patient. Known traditionally as bedside manner, these may be critical instructions on self-care, or may be the casual words that offer the patient hope, support, comfort, and esteem. A nurse may be viewed as being positive and caring by being compassionate, genuine, and sympathetic, or alternately display the negative traits of arrogance, rudeness, or indifference (Person and Finch 6-7). This alters not only a patient's view of the hospital and its level of care, but may also have more lasting implications. According to Person and Finch, "the patient's perception of provider bedside manner impacts health status, satisfaction, and compliance" (Person and Finch 1). A nurse may need to communicate instructions that are necessary to maintain the patient's follow up care after they have been discharged from the hospital. This may be in a context where death, illness, and family wishes need to be considered from a cultural vantage point. The nurse may be the most vital actor in explaining and clarifying the information that the physician gave a patient during a hurried period of anxiousness (Ufema 70). The nurse can bridge the critical gap between 'cure' and 'care', and begin to communicate in terms of peace and closure, rather than the more technical language that might be expected from a physician (Ufema 70). If the
Tuesday, September 24, 2019
Food, Inc Essay Example | Topics and Well Written Essays - 500 words
Food, Inc - Essay Example coli is the corn that the cows are fed. It is quite cheap and dangerous for health. The content of E. coli in the cow’s guts increases when they feed on the corns. In order to regulate the effect of increased E. coli level, the meat packers often tend to cleanse the meat by treating it with ammonia so that it becomes suitable for human consumption. Food borne illnesses resulting from the consumption of contaminated food are increasingly putting millions of Americans in hospitals every year. The number of Americans that are admitted into hospitals every year is 325,000 approximately and those who die because of the diseases caused by contaminated food consumption every year are about 5000 (The Center for Ecoliteracy 39). The toddler Kevin in Food, Inc. who is only two years old becomes sick because of Escherichia E. coli. Escherichia E. coli is a bacterial group which is found in the intestines of many birds, animals and also humans. Usually, many E. coli benefit us by decompos ing the food that we in-take and facilitate its digestion, though serious infections may be caused by some strains that may in turn, cause bloody diarrhea, cramps in the stomach, failure of kidney and sometimes, it may result into the death of the affected person. People may acquire the bacteria of E.
Monday, September 23, 2019
Benefits of immigration Research Paper Example | Topics and Well Written Essays - 1250 words
Benefits of immigration - Research Paper Example ds that may lead to influx of population, additional spending on the welfare in order to provide them housing, employment, education and other basic facilities. Coppel, Dumont and Visco (7) mentioned that United States is the major country that is receiving immigrants in huge numbers among the OECD countries. Most of migration policies accept immigrants in form of visitors, family reunion allowing the family members to stay permanently, asylum seekers; skill based migration and on the basis of naturalization rules. The policies defined by the nations not only allow migration of people but also benefits the host country economically and culturally which is analyzed in the present paper. Most of the policy makers debate upon the role of immigration that can ease the economic and budgetary impacts of declining and ageing OECD populations and addressing skilled labor shortages in various sectors (Coppel, Dumont and Visco, 4). Most of the nations would benefit from the immigration as it will lead to inflow of people into the market benefiting the native born population. Immigrants will buy goods and services from the native industries resulting in increased profit to the native firms and people (Novelguide.com, 14). According to recent report by Dr. Raul Hinojosa-Ojeda, it is found that comprehensive immigration reform will enable future flow of legal workers resulting in large economic benefit of $1.5 trillion in US GDP over the next 10 years (Immigration Policy Center, 1).The benefits of additional GDP growth would be spread throughout the US economy and higher earning power of newly legalized workers will result in the increase of tax revenues of $4.5 to 5.4 billion and will stimulate the economy giving rise to services in banking sector, housing and business. United Kingdom, too, witnessed growth in its GDP due to immigration and allowing the employers greater choice in a wider labour market and to find better match between vacancies and available labour (UK
Sunday, September 22, 2019
Guide to Psychiatric Museum Synopsis Case Study Example | Topics and Well Written Essays - 500 words
Guide to Psychiatric Museum Synopsis - Case Study Example Not only does it receive all of its funding and institutional support from Creedmoor, but all the artists (except for Bolek) use the hospital's services. According to Charlotte Seltzer, Creedmoor's director, Creedmoor has changed quite a bit since the mid-1970s when it earned its reputation as an institutional nightmare. Though still considered as the largest psychiatric hospital in New York City, Creedmoor has shrunk in the last three decades to one fifth its former patient population. At its height, Creedmoor had more than 7,000 patients. Structured craft and expressive art activities both have a place in treatment of mental health disorders. In structured crafts, the limits of repetitive and predictive project can offer reassurance to the fearful person and help contain anxiety. Patients seem to prefer projects with true boundaries, such as plastic "stained glass", sophisticated colored sheets, and mosaics. Completing these tasks successfully also provides a sense of mastery through accomplishment and increases patients' perceived sense of effectiveness. The more expressive artwork may offer a release of tensions through physical activity, such as ripping paper or using a stippling brush for painting de
Saturday, September 21, 2019
Project on Motivation of Nurses Essay Example for Free
Project on Motivation of Nurses Essay The most traumatic and stressful moments of an individual’s life are when he or she is taken ill. Nurses are synonymous with care and attention in times of need such as these. In a world mostly driven my personal ambition and corporate profit, nurses with their commitment to patient welfare and selfless service, provide a contrasting study. A nurse acts as a savior in distress and is often called upon to make great personal sacrifices in the discharge of her duties. The profession of nursing, is therefore, not merely a ‘job’ and the potentially powerfully insights about commitment to work that they could provide encouraged us to choose them as our subjects of study. As part of the Phase I of the project, we interviewed four nurses who were diverse in the amount of experience each had, the hierarchy in which they were working in the hospital and the backgrounds from which each of them came. This was done to study the commitment of employees towards an organization and understand the various factors which cause the same we have selected a study of nursing staff in hospitals. From the interviews, many broad themes emerged, all of which point correlate positively with their high commitment level to the organization. These points logically lead us to our hypothesis as to what keeps them committed to their place of work.  However, there were some key themes which we noted across all four of our respondents. All the nurses were very excited by the kind of recognition that the hospital was willing to give them. They seemed to treat this as a reward for their hard work and dedication and were motivated by it. All nurses were also impressed by their working relationship with their superiors (Head Nurse/Doctor) in the hospital who treated them as members of a family and with much respect. Nurses were also willing to stay on with the hospital because it provided them with opportunities for personal development. Accordingly our hypotheses are as follows: * There is a positive correlation between the amount of recognition that the nurses receive for their work and their commitment to the organization * There is a positive correlation between the positive relationship between the doctors/supervisors and the nurses and the commitment of the nurses to the organization * There is a positive correlation between the opportunity for learning and personal development that the organization provides and the commitment of the nurses to the organization RESEARCH METHODOLOGY Based on our earlier survey of 4 respondents, we determined that the following three variables play a key role in determining the commitment of nurses to their respective hospitals: * Recognition * Relationship with superiors * Learning and Development We have then tried to identify whether these three variables actually affect commitment levels of nurses at various nursing organizations. For the same, we carried out a survey of 30 nurses with diverse backgrounds (a detailed description of the respondents is covered in the following section) and questioned them on a scale of 5 to 1 (5: Strongly Agree, 1: Strongly Disagree) on 24 questions. Since our hypothesis determines 3 variables as affecting commitment, we tested the existence of each these three independent variables by framing four questions for each variables. Similarly, we determined commitment levels of the nurses through a set of 12 questions. By using a 5-point scale, we have captured not only the existence, but the extent of existence of these variables. Since we found the responses to be reliable, we determined the correlation between the three independent variables and the dependent variable ‘commitment’ to see whether our hypothesis of is correct. Hospitals chosen for the survey We surveyed nurses from 4 different hospitals to ensure diversity. The organizations range from a large hospital located in a city like Bangalore, to mid-sized hospitals located in Tier-2 cities like Ajmer and Allahabad and a focused surgical-specialty hospital located in a smaller town like Varanasi. This selection lends diversity to our respondents through differences in location, specialization of hospitals, daily footfall (reflecting magnitude of work for the nurses), number of departments etc. Refer Appendix 1 for a description of the hospitals used for out survey. General Profile of the Nurses We have ensured diversity in our respondents while choosing nurses at all of the survey hospitals. The diversity ranges age, number of years worked at the organization and departments worked in. QUESTIONS IN THE SURVEY The questions in the survey were aimed at understanding the extent to which each of our three independent variables and our dependent variable ‘commitment’ was present in these organizations. We captured the different parameters relating to these variables by framing questions addressing various facets of these variables. Refer to Appendix 2 for detailed discussion on questions used for the survey. ANALYSIS OF RESULTS OF THE SURVEY Reliability of scales Reliability is used to check the consistency of the question set under consideration. In this survey we are testing if the 3 hypothesis that we have come up with are explaining the commitment of employees towards organization. Reliability in a survey is measured by lot of ways and here we are checking internal consistency reliability which indicates reliability within the survey for the responses of similar type of questions. Reliability of dependent variable * Affective Commitment: In affective commitment the questions that are all trying to test for one feature- Attachment to Organization. The questions are direct and straight forward bringing out the required feature thus making it a set of good reliability. We have obtained a reliability scale of 0.6 for this set which is the highest amongst the 3 different commitments scales that we have obtained. * Continuance Commitment: In this set we are trying to test the commitment by knowing the dependence of the person on the organization and how much of a change it would mean to him to switch jobs. The reliability that we obtained for this set is 0.53 which is a high value for a one time survey result. This is a good indication of question set focusing on the same core question. * Normative Commitment: This question set mainly tries to identify the belongingness the person has towards the organization. The question set is clear in conveying the same objective but this attribute is not so direct and easy to understand from an individual’s perspective. Hence the survey respondents’ answers in this set have a lower value reliability of 0.39. Reliability of independent variables For first and third variables (recognition and learning development), the reliability is low at 0.46 and 0.47 respectively while for the second variable (relationship with superiors), the reliability is relatively high at 0.66. Recognition and Learning Development It’s easy to see why responses to questions around Recognition and learning and development score so low in reliability. They are quite different from each other and same person can have very different responses to each of them, if they interpret the different questions to indicate different things. In comparison the questions related to relationships were fairly interrelated and are able to fetch more consistent responses. Overall reliability of all the responses is still lower than 0.7 which can be attributed to the fact that no pilot study was done, which could have been used as input for framing questions in a better way as to improve reliability of responses. Relationship with superiors We obtained highest reliability for responses for this hypothesis. Reliability for this was found to be 0.66, which is near acceptable range. The reason for higher reliability in this question set (Appendix 2) is attributable for ease of understanding the questions. Every person has a fair idea about relationships and these questions although quite different from each other give a fairly good direction the responder in terms of what is being asked. So they maintain consistency and hence higher comparative reliability. Correlation between predictor and dependent variables a) Affective Commitment According to our expectation before the actual test results we came up with all 3 predictors are going to affect the Affective commitment. Recognition was one factor because the appreciation helps the employee (nurse) develop a connect with the organization. Also opportunities for personal development and training opportunities to assist this makes employees feel good which is essential to improve the commitment levels. Good relationships with superiors definitely help people develop an emotional bond with the organization. b) Continuance Commitment Continuance commitment describes how the employee feel about staying longer in the organization and for this one of the most important reasons is economic considerations which are to some extent explained by rewards and recognition. The recognition obtained will motivate them to work better and stay longer in an organization. Also constant opportunities for growing and training will help them stay committed to organization. c) Normative Commitment This form of commitment mainly explains the sense of giving back to the organization and the predictor which we identified was most important was the relationships with supervisor (Head nurse/Doctor). Training and developments reflect investment done by organization on employees, so employees feel an obligation to stay committed to organization to pay it back, which increases their normative commitment. Actual results: Statistical Significance of correlations With the acceptable alpha level being 0.05 for social science research and no. of responders being 30, (Dof = 28) gives critical value of correlation as 0.361. When compared with the results we obtained we notice that out of 9 correlations, 3 are not significant (value less than 0.361) and 6 are significant (Value higher than 0.361). When it’s significant we reject null hypothesis of no relationship and accept alternative hypothesis of existence of relationship. Hypothesis 1: From the results it’s apparent that hypothesis 1 is partially supported as only one correlation is significant out of 3. That is with affective commitment. So we can interpret that Recognition affects affective commitment but not the other two types of commitments. Hypothesis 2: For second hypothesis 2 out of 3 correlations are significant so it’s also partially supported. Relationship with doctors is not related to continuance commitment but related to affective and normative commitment. Hypothesis 3: Hypothesis 3 is completely supported as all the correlations are significant i.e. higher than 0.361. It means learning and development is related to all the dependent variables and affects all three dimensions of commitment i.e. Affective, Continuance, Normative which are considered here. Plausible explanation of variations between correlations Recognition: Recognition showed the highest correlation with affective commitment, while significant correlations were not established with the continuance and normative commitment. When nurses are recognized by the organization they tend to develop an emotional connect with the organization. They feel happier working in the hospital and a sense of belonging is nurtured within them. The appreciation received for the work translates into an attachment with the organization. This explains the correlation with affective commitment. The recognition is mostly in the form of awards and words of praise not monetary in nature. Therefore a significant continuance commitment has not been established. Similarly, recognition for work does not lead to a feeling of obligation towards the organization. Rather, the positivity generated by the appreciation of work manifests itself as an emotional attachment towards the organization, which is reflected in the correlation with affective commitment. Relationship with superiors: This independent variable showed highest correlation with normative commitment and lower correlations with affective commitment, while correlation with continuance commitment was insignificant. The nurses tend to view the exceptionally good relationships with the doctors as being facilitated by the hospital. They therefore feel indebted to the hospital for providing them with an excellent working environment, which would be missing at other places. The moral obligation that they feel towards their hospital for the respect and dignity with which doctors and supervisors treat them is translated into a high correlation for normative commitment. Learning and development: It is seen from the results of the survey that learning and development has a high correlation with Affective Commitment to the organization and comparatively low correlation with continuance and normative Commitment. Intuitively we expected high correlation between learning and development a nd normative commitment to the organization. This is because employees would feel an obligation towards an organization that invests time and resources to train its employees and ensure their personal development. However, we realize these may not necessarily hold true once we take into account the atypical nature of the nursing profession. Nurses feel sense of duty towards their patients and ethical and moral obligation to serve the sick to the best of their capacity. In fact, nurses who have been trained well, dealt with varied patient cases and experience a great deal of learning would perhaps experience higher motivation to the society. Hence perhaps they would experience low moral responsibility to staying back in the organization. We believe existence of a caring and people centric management could be the reason for the high correlation between affective commitment and learning and development. An organization that has caring and people friendly management would earn emotional loyalty from its employees due to care and good treatment given to employees. Such an organization would also take efforts to ensure that its human resources constantly learn and develop so as to contribute to the success of the organization.
Friday, September 20, 2019
Assessment Frameworks of Multiple Stressors
Assessment Frameworks of Multiple Stressors A review of environmental and human health risk assessment frameworks of multiple stressors: the case of endocrine disruptors Abstract This review is a compilation of the recommended approaches and methods for the development of a risk assessment framework of multiple stressors. Some of the driving forces contributing to address this subject are the current demands of stakeholders like the drinking water industry, the society and regulators of evaluating the risks of mixtures of contaminants that may harm human beings and the environment. Therefore, our work aims at exploring the possibility of integrating within the risk assessment, environmental, human and societal aspects, acknowledging new international regulations and policies for the safe use of chemicals which enforce the integrative study of the hazards of multiple chemicals on humans and the environment throughout their life-cycle. We chose the group of compounds called endocrine disruptors as an example of multiple stressors because of their emerging relevance and the fact that they usually integrate complex mixtures, originate from multiple sources and ex ist in several environmental compartments, generating adverse effects on receptors through different routes and pathways. Their actions may be severe chronic and long-term modifications of the normal development and reproduction patterns of the individual and/or its progeny, eventually representing systemic risks at the population level which may affect sustainability and biodiversity. Due to the ubiquity of these chemicals, it is necessary to address the inclusion of human beings as potential receptors and deal with risk assessment in an integrated manner. As endocrine disruptors may provoke differentiated responses relative to the developmental stage, acting through varied mechanisms and at very low concentrations, with the particularity that their toxicokinetics may present sometimes unusual dose-response curves, might challenge long-term predictions and hazard characterization, adding to risk assessment uncertainties. References to the current methodologies including the applica ble bioassays, chemical analysis, modeling, statistics tools and equations to calculate joint effects considering the interactions of toxicants within a mixture are also discussed in this review. KEY WORDS: risk assessment, endocrine disruptors, multiple stressors 1. Introduction The aim of this review is to analyze the risk assessment frameworks and current practices, the integration of environmental and human health methodologies, the effects evaluation and how to assess the risk of complex mixtures of chemicals. Assessing the risks of multiple stressors for human health and the environment arises from the realization that biological and physical stressors usually coexist in complex mixtures in the natural and constructed environment, sometimes generating impacts on living creatures. Historically, since the publication in 1962 of the book â€Å"Silent Spring†, by Rachel Carson, a warning on the deleterious actions on wildlife of persistent toxicants, such as DDT, which caused a decrease of birds in Pennsylvania, became presentwas recognised among the scientific world, the media and the society. More recently, the research by Dr. Theo Colborn on the reproductive disorders of predators in the Great Lakes of North America and her book, published in 1996 â€Å"Our Stolen Future†co-authored by herself with Dianne Dumanoski and John Peterson Myers, was able to generate public awareness on the threats that EDCs might pose to human beings and the environment. Some of the driving forces for writing this review are the demands of stakeholders represented by the community, the NGOs, the health and environmental regulators, the manufacture industrial sector and the drinking water companies. For instance, the European Environment and Health Strategy emphatically stresses the gaps in knowledge related to risk assessment methodologies that include foetuses, infants and children and calls for the precautionary principle within the strategy for environmental contaminants, for which there is a sufficient level of scientific evidence at the effect level (e.g. molecular, cellular, or tissue-related) to show the likelihood of health impacts. Not enough information exists on the link between emissions of dioxins and PCBs and other substances and their accumulation in ecosystems and foodstuffs. The need for research on the understanding of the links between environmental factors and certain diseases is recognized, but, due to the complexity of the issue , the immediate action is to gather evidence in order to concrete measures to protect human health and the environment. Many reports are able to demonstrate through laboratory experiments and field surveys that exposure of animals to chemicals released into the environment exert reproductive or developmental effects on the individual and its off-spring, affecting the viability of the species at a population level (Colborn and Smolen 1997). As a matter of fact, these kind of adverse effects have been observed in wildlife and many of them can be attributed to the exposure to man-made chemicals. The cause-effect relationship is still controversial in human beings, but still a matter of concern due to the severity of probable harm that could affect individuals and populations. Thus, regulatory decisions must be informed by risk assessment on this important topic (Fenner-Crisp 2000). Endocrine-mediated effects may be more relevant in populations rather than in individuals. As there is still not consensus about a cause-effect relationship, it is recommended a science-based precautionary approach to protect public health. Further research is needed to demonstrate effects and carry out birth defect registries and epidemiology studies designed to track delayed effects of environmental exposures (Solomon and Schettler 2000). The classical paradigm of human health risk assessment authored by the National Research Council (NRC, 1983) is composed of four steps: hazard identification, dose-response assessment, exposure assessment and risk characterization. This paradigm was modified in 1994 to include characterization of each component. One of the approaches considered by some authors as best suited for developing a risk assessment of multiple stressors is a cumulative risk assessment framework, which may include societal aspects with participatory involvement of stakeholders (Gentile and Harwell 2001; Callahan and Sexton 2007; USEPA 2003). The global trend towards a policy-driven integration applied to risk assessment, demanded by regulations on safety of chemicals and industrial operations should ideally include a multiplicity of stressors, compartments, geographical scales, and end-points (Assmuth and Hildà ©n 2008). For example, the new European Union Regulation on chemicals and its safe use (REACH, EC 1907/2006) enforces linking risks to human health and the environment for chemicals throughout their life cycle. In United States, the Environmental Protection Agency, still discusses both topics separately because of practical reasons, but acknowledging the need to integrate them. An overview of the most suitable risk assessment frameworks is described in this literature review, focusing on the case of mixtures of reproductive endocrine disruptors. Matters that differentiate this topic are also presented, regarding particularities in mechanistic and toxicokinetics aspects and some of the sources of uncertainties and confounding factors. Developing a novel approach to the classical risk assessment scheme is also a goal, with the intention of contributing to design a risk assessment framework comprising a choice of tests, models, computational and statistical tools. 2. Hazard identification In this stage the nature of the hazard is described taking into account toxicity data. The hazard can then be characterized deriving numerical values of acceptability of the risk, based on mechanisms of action, biological extrapolation, dose-response and dose-effect relationships, and related uncertainties (Fenner-Crisp, 2003). 2.1. Nature of the hazard Endocrine disruptors (EDCs) are substances that interfere with the endocrine system by changing homeostasis and producing developmental effects and/or diminishing the fertility of the organisms. EDCs include a broad range of substances which can be classified according to their effect. The best known are the environmental estrogens, alkylphenol and its ethoxylates, the monomer in polycarbonate manufacture bisphenol A, some pesticides and chlorinated organics. 2.2. Sources of EDCs Possible sources of watercourses pollution with EDCs are wastewater sewage discharge, industrial effluents, or point and non-point source contamination of watercourses with agrochemicals such as herbicides or pesticides. Sewage discharge from cities contains residues of domestic products such as personal care products, pharmaceuticals and detergents and excreta with natural and artificial steroidal hormones from contraceptive pill usage. Nonylphenol (NP) is a highly hydrophobic bioccumulating biodegradation by-product of nonylphenol ethoxylate non-ionic surfactants which persists in sewage sludge and river sediments. Its use and production have been banned in EU countries and strictly monitored in many other countries such as Canada and Japan (Soares et al. 2008). Pulp mills are some of the industries associated to studies on endocrine disruption. Bleached Kraft pulp mill effluents have been linked to both estrogenic and androgenic effects on biota, depending on the process characteristics and wastewater treatment. Several studies have associated the chlorination of organic matter to the estrogenicity of the effluent. Nowadays, the application of elemental-chlorine-free processes has diminished the risk of dioxins and furans formation, but not eliminated it, as other halogenated organics are formed by use of chlorine dioxide as bleaching agent. Various wood-extractive compounds produced in the pulping process, such as rosin acids and phytosterols and found in pulp mills effluents have also been considered potentially responsible of endocrine disruption (Hewitt et al. 2008). The main identified resin acids in pulp mill effluents are: pimaric, isopimaric, sandaracopimaric, palustric, dehydroabietic, abietic and neoabietic acid (Merilà ¤inen and Oikari, 2008). Other compounds found in this type of effluent are phenolic guaiacyl-based lignin degradation products, diterpenoids, and dimethoxy stilbene (Belknap et al, 2006). Modern analytical methods, like full-scan GC-MS have been used to identify wood related extractives in final effluent from a chlorine dioxide bleached pulp mill effluent, including monoterpenes, phenolics, fatty acids, resin acids, resin acid neutrals and sterols (Wartman et al. 2009). Receptor binding bioassays for androgens and estrogens indicated that androgens were most abundant in this effluent and the range of androgens for the various extraction protocols used was 189-283 ng/L as testosterone equivalent concentration. Some examples of common sources of EDCs and typical environmental concentrations are summarized on Table 1. Table 1.Sources of EDCs and typical environmental concentrations Origin, use and occurrence Source of environmental exposure EDC group Example molecule Typical concentrations Reference Industrial (pulp and paper mills) Contaminated fish Resin acids pimaric acid 4-140  µg g-1 Owens et al, 1994 Industrial (pulp and paper mills) Industrial wastewater treatment plant Chlorinated organics 2,4,6-trichlorophenol 1.5  µg l-1 Owens et al, 1994 Industrial (pulp and paper mills) Final stage secondary treatment Phytosterols ÃŽ ²-sitosterol 58.42  µg l-1 Landman et al, 2008 Domestic, (contraceptive pills) Sewage effluent Pharmaceuticals 17ÃŽ ±-ethynylestradiol 14-17 ng l-1 Liu et al, 2004 Human and animal excreta Sewage effluent Natural steroid hormones 17ÃŽ ²-estradiol 5.0 ng l-1 Koh YKK et al, 2007 Domestic and industrial (laundry detergents, wool scouring processes) Sewage sludge Non ionic surfactants 4-nonylphenol 829.3 mg/kg Gonzà ¡lez et al, 2010 Domestic and industrial (polycarbonate bottles) Leaching from solid waste, sewage effluent Polycarbonate bisphenol A 0.62  µg l-1 Sà ¡nchez-Avila et al, 2009 Agricultural (soil fertilization) Livestock waste Male steroid hormones testosterone 10-1830 ng l−1 Lange et al, 2002 Agricultural (dairy farming) Streams contaminated by dairy cow excreta Female steroid hormones 17ÃŽ ²-oestradiol 0.04-3.6 ng l−1 Matthiessen et al, 2006 Agricultural (weed and grass control in soybean crops) Run-off Herbicide glyphosate 0.1-0.7 mg l-1 Peruzzo et al, 2008 2.2. Dose-response assessment There are several methods to demonstrate dose-response relationships, either by in vivo or in vitro tests. Fish reproduction tests, like the ones using the model fish fathead minnow (Pimephales promelas) have shown a decrease in fecundity associated with depressed steroid and vitellogenin (Vtg) production in female specimens (Ankley et al. 2008). Many of the tests rely on the measurement of an increase of Vtg as biomarker of estrogenicity as seen in several publications (Schwaiger et al. 2002; An et al. 2008; Holbech et al. 2006 Panter et al, 1998; Sohoni et al. 2001; Kunz and Fent, 2009). Tests results on resin acids show different responses in the first generation of fish than in the second (Christianson-Heiska et al. 2007). In some cases there are not many examples of in vivo tests, like for glyphosate. A fish exposure tests with this compound showed Vtg induction in female fish, indicative of estrogenic activity (An et al, 2008). An investigation working the commercial formulation of the herbicide glyphosate and human placental cells demonstrated its toxicity at concentrations lower than the usual in agricultural practices. The aromatase activity disruption seems to be due not only to glyphosate but also to co-adjuvants (the surfactant nonylphenol or others), which enhance its bioavailability and/or bioaccumulation (Richard et al. 2005; Gasnier et al. 2009). Table 2 shows some examples of dose-response experiments working with fish, crustacea, molluscs and amphibia. Varied protocols exist to develop ecotoxicity tests, in flow-through, static or partly renewal conditions, and with different duration and end-points. Only chronic effects and particularly developmental and reproductive effects were conside red. Table 2. Dose-response for endocrine disruption effects in freshwater organisms exposed to single EDCs EDC chemical name Taxonomic group Species Dose to produce effect Effect Test conditions Reference 4-nonylphenol Fish Rivulus marmoratus 300  µg l-1 Testicular agenesis and oogenesis inhibition in 100 % fish Static system, daily renewal Tanaka and Grizzle, 2002 4-nonylphenol Fish Oncorhynchus mykiss, rainbow trout 1 -10  µg l-1 10  µg l-1 High Vtg in adult male fish plasma Low hatching rate Intermittent exposure of adult fish for 4 months until spawning Schwaiger et al, 2002 4-nonylphenol Crustacean Ceriodaphnia dubia NOEC for reproduction: 1  µg l-1 Low hatching rate 7 days chronic exposure, static Isidori et al, 2005 Glyphosate Fish Carassius carassius, crucian carp 100% effluent Vtg induction in female fish (38.6 +/- 9.8  µg l-1) 3 weeks, continuous exposure An et al, 2008 Glyphosate Mollusk Pseudosuccinea columella, aquatic snail 1 mg l-1 10 mg l-1 Faster development of F3 embryos Hatching inhibition 3 generation continuous Tate et al, 1997 Estrone Fish Danio rerio LOEC: 14 ng l-1 50 ng l-1 Significant Vtg increase Higher female ratio 40 days fish sexual development test Holbech et al, 2006 17ÃŽ ²-Estradiol Fish Danio rerio LOEC: 54 ng l-1 Significant Vtg increase Higher female ratio 40 days fish sexual development test Holbech et al, 2006 17ÃŽ ²-Estradiol Fish Pimephales promelas, fathead minnow 100 ng l-1 Significant Vtg increase Testicular growth inhibition 21 days male fish exposure Panter et al, 1998 Estriol Fish Danio rerio LOEC: 0.6  µg l-1 21.7  µg l-1 Significant Vtg increase Higher female ratio 40 days fish sexual development test Holbech et al, 2006 Dehydroabietic acid (DHAA), resin acid Fish Danio rerio, zebra fish 50  µg l-1 Low plasma Vtg in female in F0; high Vtg and affected spermatogenesis in F1 males 2 generations, continuous Christianson-Heiska et al 2008 ÃŽ ²-sitosterol Fish Danio rerio 10-20  µg l-1 F1: higher ratio of male fish; F2: higher ratio of female fish 2 generation fish exposure test Nakari and Erkomaa, 2003 Quercetin, phytoestrogen Amphibian Xenopus laevis, frog 200  µg l-1 Higher female ratio > 10% abnormal testes (some with ovotestes) Exposure up to 1 month post-metamorphosis Cong et al, 2006 Phenanthrene, PAH Fish Oryzias latipes, Medaka NOEL: 100  µg l-1 Developmental, hatching 18 days, renewal Rhodes et al, 2005 Bisphenol A Mollusk Marisa cornuaretis, aquatic snail NOEC: 640  µg l-1 Developmental 12 weeks, juvenile snails Forbes et al, 2007 Bisphenol A Fish Pimephales promellas 16  µg l-1 640 and 1280  µg l-1 640  µg l-1 1280  µg l-1 Altered spermatogenesis Growth inhibition and Vtg induction in male fish Reduced hatchability in F1 generation Egg production inhibition 3 generation reproduction exposure test Sohoni et al, 2001 Bisphenol A Fish Brachydanio rerio, zebrafish EC50: 2.90  µg l-1 Embryo malformation and low hatchability 72 h exposure Liu et al, 2007 Benzo-ÃŽ ±-pirene (BaP) (PAH) Fish Fundulus heteroclitus , common mummichog 10  µg l-1 CYP19A1 expression decreased by about 50% in immature stage I oocytes Exposure for 10 or 15 days by in situ hybridization, several developmental stages Dong et al, 2008 Polychlorinated biphenyl 126 Fish Danio rerio, zebrafish LC50: 3.270 mg l-1 Developmental effects through aryl hydrocarbon receptor activation Dilutions of PCB 126 for 12 weeks SiÃ…Å ¸man et al, 2007 Polychlorinated biphenyl 126 Fish Salvelinus namaycush, lake trout 3 ÃŽ ¼g kg−1body weight Retinol depletion Oral exposure for 12 weeks; confirmation with radiolabelled retinol Palacea et al, 1997 Benzophenone-1 Fish Pimephales promelas 4919  µg l-1 Vtg induction 14 days exposure, semi-static, renewal Kunz and Fent, 2009 3. Exposure assessment 3.1. Ecosystems and human sub-populations potentially at risk of endocrine disruption effects Increasing evidence generated by scientists turn endocrine disruption into a recognized risk to the environment. Due to the ubiquity of EDCs and the widespread routes of exposure, most ecosystems and human populations are potentially at risk of endocrine disruption. Notwithstanding this fact, under the scope of a risk assessment of EDCs the potentially most vulnerable risk subgroups are identified corresponding to maternal, fetal and early developmental stages. The concern that prenatal or childhood exposure to EDCs may be responsible for abnormalities in human sexual and reproductive health are still in the hypothetical ground. However, many reports on exposure to high concentrations of recognized EDCs such as DES, certain PCBs, and DDT demonstrate this fact. At low-doses the question remains unanswered whether there could be a critical window where they could harm the fetal development (Hood 2005). Several reports on human developmental anomalies and reproductive ailments have been raising international concern, such as a seven fold increase risk of testicular cancer since 1969 to 2002 in men from several countries of Europe, United States and New Zealand. Also, the sperm density halved, as rates of cryptorchidism (undescended testicles) and hypospadias (shortened urinary tracts) simultaneously rose. It is thought that human congenital malformation of sex organs, low sperm quality, endometriosis, reduced fertility and some types of cancers of breast and testis could be linked to exposure to EDCs. More than 80000 synthetic chemicals are produced in the world and have still not been fully evaluating with regards to endocrine disruption. In 1996, the U.S. Environmental Protection Agency initiated an Endocrine Disruption Screening Program to evaluate more than 15,000 chemicals calling for a policy based on the â€Å"precautionary approach†to be overcautious and protect huma n health and the environment. A historical example of policies which demanded the banning of a drug due to these after-effects is the case of diethylstilbestrol (DEADES), which used to be prescribed to pregnant women to prevent spontaneous abortions because it produced higher risk of genital deformities and cancer in the offspring, among other effects (Stair 2008). Internationally there is consensus that the most vulnerable group for EDCs exposure are children. For example, in European countries, the Strategy for Environment and Health known as â€Å"SCALE†for Science, Children, Awareness, Legislation and Evaluation, has set as a priority agenda for the evaluation diseases caused by endocrine disruptors in children. The exposure to insecticides and herbicides used in agricultural practices has been linked to developmental or reproductive effects in wild animals and also in human beings. The occupational exposure to pesticide has received much attention, as for example prolonged time-to-pregnancy was observed in male greenhouse workers exposed to pesticides before conception of their first pregnancy (Bretveld et al 2008). The domestic exposure of children to residues of pesticides in low-level long-term exposures are associated to chronic effects and include routes of exposure such as fruit or breast milk (Goodman and Laverda 2002). 3.2. Evidence of endocrine disruption effects in wildlife around the world There are reports on impacts on wildlife reproduction and development observed in invertebrates, fish, reptiles, birds and mammals, sometimes confirmed by laboratory tests. In laboratory experiments the impacts to fish populations by EDCs affect reproductive health and persistence of various fish species (Mills and Chichester 2005). Many examples of impacts due to exposure to endocrine disruptors exist in wildlife, such as the seals population decline in the Baltic and North Sea, the high levels of female egg yolk in male fish or snail imposex and intersex around the world. Intersexuality of fish has been demonstrated in several investigations carried out in rivers around the world. The findings of abnormal reproductive female-like ducts and oocytes in male fish were related to the treated sewage discharge from the cities in laboratory experiments measuring induction of plasma vitellogenin in exposed male fish (Jobling et al. 2002). Field studies were carried out using wild roach as a model fish to confirm the incidence and the severity of intersex which correlated with the predicted concentrations of the natural estrogens (E1 and E2) and the synthetic contraceptive pill estrogen (EE2) present (Jobling et al. 2006). Some case-studies have made clear that the estrogenic activity of municipal wastewater correlates to demographics. The number of inhabitants was found to correlate with changes in estrogenic activities in a research conducted at a university city in US, with seasonal fluctuations in population. The concentrations of synthetic and natural estrogens and other EDCs were measured and effects demonstrated through the application of in vivo and in vitro tests (fish exposure with Vtg induction measurement and the yeast estrogen screen) (Brooks et al. 2003). The demonstration of effects of pulp mill effluents has also been supported by fish surveys with a sampling design that includes upstream and downstream sites from the discharge pipe of the pulp mill. For instance, Munkittrick et al. (1994) have demonstrated that the absence of chlorine bleaching or the presence of secondary treatment does not eliminate estrogenic responses evidenced by decreased circulating levels of sex steroids, decreased gonadal size, which implies that there may be multiple causative agents. In other cases, androgenic effects have been noticed, such as a biased male to female ratio in fish in Sweden downstream from pulp mills (Larsson and Fà ¶rlin 2002). As seen on Table 3, several adverse endocrine effects are evidenced in various animals, from mollusks to amphibian but they also appear in higher animal species. Table 3. Effects of EDCs in wildlife evidenced through field studies Animal Effect EDCs Postulated mechanism or causative agent Reference Frog High incidence of deformed frogs in Minnesota, United States Multiple EDCs Retinoid signaling pathways activation Gardiner et al. 2003 Marine Gastropods Masculinization of female snails (imposex) occurs worldwide. Females grow accessory sex organs including sperm ducts, seminal vesicles, external sperm grooves, and penises. Exposure to low levels of tributyltin (TBT) (1ng/l) Aromatase inhibition, testosterone inhibition, or neuroendocrine disorder or interaction with retinoid receptors Novà ¡k et al. 2008 Wild roach (Rutilius rutilus) Intersex, and high plasma Vtg concentration Multiple EDCs Sewage effluent from wastewater treatment plant discharging into rivers Joblin et al. 2006 Mosquitofish (Gambusia affinis) Masculinization (90% affected in number of segments in the longest anal fin ray). Androgen-dependent gene expression by luciferase test Kraft pulp mill effluent Affinity for human androgen receptor (hAR) Parks et al. 2001 Eastern Mosquitofish, (Gambusia holbrooki) Androgenic activity measured by androgen receptor transcription assay with human receptor in sediment. Fish masculinization. Paper mill effluent, river Pine pulp-derived phytosteroids accumulate in river sediment where they are converted by microbes into progesterone and this into androstenedione and other bioactive steroids Jenkins et al. 2003 3.3. Conceptual model Deriving a conceptual model requires knowing the pathways and toxicokinetics of the EDCs identified in the hazard identification step. An effects-based assessment start by identifying the effects and the relevant stressors and geographically located (for example through the use of GIS software). On the other hand, the model used in stressor-based assessments, depicts how stressors affect receptors and it is commonly applied when evaluating risks of environmental pollution. If a river basin is evaluated, the sources of contamination are studied, identifying the pathways, receptors and effects. To develop the human health risk assessment component, the fish consumption of the population and the drinking water intake are two of the main factors to consider especially for the most vulnerable population, which are newborn and lactating infants. The food chain is the main source of exposure, and in particular, fish consumption and drinking water are possible sources for the nursing mother and the pathway of distribution through the milk to the baby, but the direct intake of drinking water is important in the case of formula preparation. The environmental risk assessment should consider fish, crustacean and sediment dwelling organisms within the framework. During pregnancy maternal fat is moved, releasing to the blood the bioaccumulated compounds, due to their liposolubility and persistence, through all the different exposure routes (foodstuffs, environmental, occupational) throughout her life. Acute exposure should also be considered if it happened previously to gestation or during this period. There are substances that traspass the placental barrier and chemicals reach the offspring. Also, through the breastmilk, explaining the extrangely high levels of some xenobiotics (Fernà ¡ndez et al. 2007). 3.4. Methodologies to determine dose-response in exposure assessment The analysis of exposure and effect determines the concentration of the EDC on the environment matrixes matrices (water courses, ground water, drinking water, soil, sediment, air, biota), and assesses the potential or actual effects. In order to do so, many tools are recommended and in general a tiered approach is the most suited for this task as it helps to work in a logical order and increasing the specificity of the tests. One of the main sources of exposure to most chemicals is through the food chain. The bioconcentration of organics in beef, cow milk and vegetation correlates to the octanol-water partition coefficient (Kow) to predict the bioaccumulation in the aquatic and terrestrial food chains (Travis and Arms 1988). There are many models based on the characteristics of the chemicals, such as the fugacity model, which allows to predict the expected concentrations in six environmental compartments (water, air, soil, bottom and suspended sediment and fish) (MacKay et al. 1985). 3.4.1. The use of a tiered methodology to demonstrate endocrine disruptive effects This type of approach is carried out including different tests, such as bioassays, in vitro tests and field studies as part of the experimental design. The methodologies generally employed are in vivo fish reproduction exposure tests and in vitro receptor binding bioassays, for androgens and estrogens (Wartman et al., 2009). Even though there is an international trend towards diminishing the use of live organisms for experimentation for safety testing, in vivo tests are still of key importance for the confirmation of the findings of in vitro screens. Some of the most utilized tests relay on the use of fish as model experimental organism in various life-stages, as for example the 21 days reproduction fish test with fathead minnow (EPA/600/R-01/067). 3.4.2. In vitro screens and tests Some of the in vitro assays that can be used as screening tools of estrogenic activity are the following: yeast based assays, cell proliferation assays, bindin
Thursday, September 19, 2019
Portland Cement Essay -- essays research papers
PORTLAND CEMENT Chemical composition. Portland Cement is made up of four main compounds: tricalcium silicate (3CaOSiO2), dicalcium silicate (2CaOSiO2), tricalcium aluminate (3CaOAl2O3), and a tetra-calcium aluminoferrite (4CaO Al2O3Fe2O3). In an abbreviated notation differing from the normal atomic symbols, these compounds are designated as C3S, C2S, C3A, and C4AF, where C stands for calcium oxide (lime), S for silica, A for alumina, and F for iron oxide. Small amounts of uncombined lime and magnesia also are present, along with alkalies and minor amounts of other elements Hydration. The most important hydraulic constituents are the calcium silicates, C2S and C3S. Upon mixing with water, the calcium silicates react with water molecules to form calcium silicate hydrate (3CaO 2SiO23H2O) and calcium hydroxide (Ca [OH] 2). These compounds are given the shorthand notations C-S-H (represented by the average formula C3S2H3) and CH, and the Hydration reaction can be crudely represented by the following reactions: 2C3S + 6H = C3S2H3 + 3CH 2C2S + 4H = C3S2H3 + CH During the initial stage of hydration, the parent compounds dissolve, and the dissolution of their chemical bonds generates a significant amount of heat. Then, for reasons that are not fully understood, hydration comes to a stop. This quiescent, or dormant, period is extremely important in the placement of concrete. Without a dormant period there would be no cement trucks, pouring would have to be done immediately upon mixing. Following the dormant period (which can last several hours), the cement begins to harden, as CH and C-S-H are produced. This is the cementitious material that binds cement and concrete together. As hydration proceeds, water and cement are continuously consumed. Fortunately, the C-S-H and CH products occupy almost the same volume as the original cement and water; volume is approximately conserved, and shrinkage is manageable. Although the formulas above treat C-S-H as a specific stoichiometry, with the formula C3S2H3, it does not at all form an ordered structure of uniform composition. C-S-H is actually an amorphous gel with a highly variable stoichiometry. The ratio of C to S, for example, can range from 1:1 to 2:1, depending on mix design and curing conditions. Structural properties. The strength developed by portland cement depends on its composition and the fineness to whi... ...s. Dust emission from cement kilns can be a serious nuisance. In populated areas it is usual and often compulsory to fit cyclone arrestors, bag-filter systems, or electrostatic dust precipitators between the kiln exit and the chimney stack. Modern cement plants are equipped with elaborate instrumentation for control of the burning process. Raw materials in some plants are sampled automatically, and a computer calculates and controls the raw mix composition. The largest rotary kilns have outputs exceeding 5,000 tons per day. Grinding The clinker and the required amount of gypsum are ground to a fine powder in horizontal mills similar to those used for grinding the raw materials. The material may pass straight through the mill (open-circuit grinding), or coarser material may be separated from the ground product and returned to the mill for further grinding (closed-circuit grinding). Sometimes a small amount of a grinding aid is added to the feed material. For air-entraining cements the addition of an air-entraining agent is similarly made. Finished cement is pumped pneumatically to storage silos from which it is drawn for packing in paper bags or for dispatch in bulk containers.
Wednesday, September 18, 2019
Thomas Edison :: essays research papers
Thomas Alva Edison Thomas Edison could probably be properly called Mr. Electricity because of the many inventions and millions of dollars that he used and invested with electricity. From the invention of the light bulb, to the invention of the phonograph Thomas Edison made electricity a reality for the masses. And one of his greatest influences was from his Father a very positive man. A long with the great influence he had upon Americans and the world. He sparked the movement of today’s computer ran world. Thomas Edison was born February 11, 1847 in Milan, Ohio. He was the seventh and last child of Samuel Edison, Jr. and Nancy Elliot Edison. His parents had no special mechanical background. His mother was a former schoolteacher; his father was a jack-of-all-trades - from running a grocery store to real estate. When Thomas was seven years old, his family moved to Port Huron, Michigan. He was a very curious child who asked a lot of questions. "Edison began school in Por t Huron, Michigan when he was seven. His teacher, the Reverend G. B. Engle considered Thomas to be a dull student."(Allen pg. 22) Thomas especially did not like math. And he asked too many questions. The story goes that the teacher whipped students who asked questions. After three months of school, the teacher called Thomas, "addled". Thomas was pissed. The next day, Nancy Edison brought Thomas back to school to talk with Reverend Engle. The teacher told his mother that Thomas couldn't learn. Nancy also became angry at the teacher's strict ways. "She took Thomas out of school and decided to home-school him."(Allen pg. 34) It appears he briefly attended two more schools. However, his school attendance was not very good. So nearly all his childhood learning took place at home. Edison's parents loved to read. They read to him works of good literature and history. They had many books that young Tom eagerly devoured. Before he was 12, he had read work s by Dickens and Shakespeare, Edward Gibbon's Fall of the Roman Empire and Decline, and more. Nancy Edison encouraged her curious son to learn things for himself. His parents were dedicated to teaching their children. They did not force him to learn about things he didn't enjoy. So he learned about things that interested him the most. When Thomas was nine Nancy Edison gave him an elementary science book. It explained how to do chemistry experiments at home.
Tuesday, September 17, 2019
Hair Gel :: Business Management Studies
Hair Gel Brylcreem (brill-cream) was created in 1929. It was also invented at the Chemico Works in Bradford Street in Birmingham. Brylcreem was the first mass-marketed men's hair care product. Its purpose is to keep combed hair in place. The shiny look it gave to the hair was also fashionable for a time. Other substances, including petroleum jelly, were in use for this purpose earlier. During this time Brylcreem had the jingle which was "Brylcreem A Little Dab'll Do Ya" which was introduced to the TV viewers at that time. This greasy substance used by men, so they could slick and style down their hair. It comes in a tube and a small amount is squeezed out, rubbed between the palms, and applied to the head. The company brylcreem has been around for a long time. They market gels, wax and cream. Brylcreem are still around today, but they are not as popular as they were back then. They also tried to come back into the market as they tried to introduce new products and new packaging which was in 2002. The problem they had was that they sat back and let other companies join in. At that time they did not market very well. So now at the moment, not that many people use the product. So this company shouldn’t really be a problem for me. Dax This Company has just started over in the UK but is quite well known in the USA. The company has been established in 1983 in the USA and brought over to UK in the year 1994. There weakness is that they are not well known but are beginning to be known quite well. They have no marketing strategies out. They have two types of waxes out on the market. One of them is called â€Å"wave and groom†and the other â€Å"short and neat†. People have made complaints about there products before. The wave and groom product because it actually sticks to your hair like glue and people also say because their product is partly made out of oil it id hard to get out of your hair. They also supply a shampoo to get the wax out but it doesn’t say that on the wave and groom tin. They are a not so big here as they are in USA so my product should be able to withstand them. TRE semme TRE semme only do only one type of wax. They also do fibre putty which is a sticky wax. TRE semme has only been marketed nation- wide from August 2004. The products they do are shampoo’s, mousse,
Ready For New Achievements Essay
To begin with, through all the writing assignments that I have written so far, I have showed to have the capacity to come out with good ideas. Thinking about possible reasons of the problem, consequences or even solutions to the topic, are all very important as the first step to begin. For instance, while writing assignment number two, I started with questions to make us think how armed guards may not be prepared to work with children, and I listed detailed examples on how its consequences can affect the kids’ welfare. In doing so, it can make the readers think profoundly, and realize that there is more to worry about over its negative consequences. In other words, deeply comprehending the topic helps to increase my and the readers’ critical thinking and develop better viewpoints and conclusions. Having good concepts, motivated me to write well-developed writings. At the same time, profound thoughts lead me to overthink about the topic and make me spend more time on my writings. Having a lot of ideas to write about are sometimes not necessary. An example of this situation is my â€Å"Kids With Better Futures†midterm writing assignment. Since this was an in class paper, I had to come out with strong and good ideas quicker than usual, but I tend to write some run-on sentences. Moreover, I couldn’t show all the ideas I had in that specific moment; because of the time I spent thinking about my main ideas. For example, I could also have written about my own experience as a child and how my parents have been a huge influence in my academic life, or how my environment and life style might affect the way â€Å"The Western†and â€Å"Chinese†parenting styles work. Lacking several ideas made me feel that I did not completely show my thoughts or even feelings about the topic, which I think is one of my biggest weaknesses. Nevertheless, this 263 ESL class has helped me to learn how I can organize my ideas in each paragraph and create good topic sentences. For instance, at the beginning of the course I did not know the correct order in which I had to write out my main ideas. I used to just write what I had in my mind, without taking into account that I was missing the organization of each paragraph, starting from the main idea, the controlling idea, paraphrase, and examples in the conclusion. As a result, my first writing assignment did not turn out that strong. But now, I know how to properly and correctly construct my paragraphs, and how to focus on each paragraph’s structure to make them look precise and clear. I took advantage of this class, learned as much as possible and I am completely prepared for the following levels.
Monday, September 16, 2019
Colloids Versus Crystalloids Fluid Resuscitation Health And Social Care Essay
Fluid resuscitation is one of the cardinal basiss for the direction of critically sick patients to cut down the mortality ( Schierhout and Roberts, 1998 ) . The fluids for resuscitation are chiefly categorized as either colloids or crystalloids. Owing to the high cost related with the colloids such as albumen, hydroxyethyl amylum, modified gelatine, dextran etc. , the effectivity and improved endurance associated of their usage for unstable resuscitation is still controversial ( Perel et al, 2007 ) . It was shown that the usage of colloids was instead associated with higher mortality rate when used in patients with traumatic encephalon hurt ( Myburgh et al, 2007 ) . Against this background of high cost and increased mortality in some instances, their usage has become really limited. Justification of the Topic The pick of fluid for resuscitation fluid used has a important impact on both patient endurance and related costs. Therefore, there is a demand to place a cost-efficient fluid with improved patient endurance in assorted critically sick patients. The purpose of the assignment is to reexamine the available literature on comparing between colloids and crystalloids as unstable resuscitations in critically sick patients and to measure its impact on clinical pattern and the consequence on short term and long term result for the patient in different clinical scenes. This will be done through critical analysis of the available grounds on the usage of these fluids. Search Scheme: The hunt for articles will affect electronic databases viz. PubMed, Medline, OVID, Cochran database and Google bookman. Merely randomised controlled tests carried out between 2000 to 2010 will be included in the literature reappraisal. The mention lists for all selected surveies will besides be explored to happen any more relevant tests and reappraisals. Keywords: Colloid, Crystalloid, Fluid resuscitations, dextran 70, hydroxyethyl starches, modified gelatins, albumen or plasma protein fraction. Search will be limited to adult topics and English linguistic communication. The literature will be critiqued utilizing the tool Critical Appraisal Skills Programme ( CASP ) and the strength of grounds will be considered based on CEBM hierarchy of grounds. Literature Reappraisal: Fluid Resuscitation: Albumin is Associated with Greater Mortality than Saline solution after Traumatic Brain InjuryLiterature ReviewThe Saline versus Albumin Fluid Evaluation ( SAFE ) Study Research workers[ I ]carried out double-blinded, randomized, controlled test to compare the consequence of fluid resuscitation with albumen or saline on mortality rates in a population of critically sick patients. This was done in ICU units of 16 infirmaries in Australia and New Zealand between November 2001 and June 2003 Intervention patients divided to two groups ; one received 4 % albumen and 2nd received normal saline for all unstable resuscitation. They were observed till decease, discharge or 28 yearss after randomization.The survey found no important difference in mortality rates between the two groups. To farther widen the survey, the research workers carried out a sub analysis i.e. a blinded, follow-up survey of 515 patients with TBI ( Traumatic encephalon hurt ) from the SAFE survey databaseaa‚ ¬ †randomized either to a saline group ( 260 ) o r to an albumen group ( 255 ) .Main intent was to measure mortality rates and functional neurological results in the albumen and saline groups at 24 months after randomisation. At 24 months after randomisation, 71 out of 214 albumens group patients had died ( 33.2 % ) vs. 42 out of 206 saline group patients.As respect to the neurological results at 24 months found in the albumen group ( 96 out of 203 ; 47.3 % ) vs. the saline group ( 120 out of 198 ; 60.6 % ; comparative hazard of 0.78 ; P=0.007 ; and a 95 % CI of 0.65aa‚ ¬ †0.94 ) . The strengths of this survey ( SAFE ) included transporting out this survey as a RCT which enabled the research workers to hold a comparing between the two groups with High-level conformity with over 97 % of patients acquiring their allocated fluid, limited concurrent intercessions, and a web-based direction system. It was a blinded survey which minimizes any allotment prejudice. This determination was consistent with consequence of systemic reappraisal and argument sing colloids vs. crystalloids for unstable resuscitation in critically sick patients which was triggered by a big meta-analysis ( by Cochrane Injuries Group Albumin Reviewers ) that suggested colloids to be associated with higher mortality rates, The failings are the patient population is significantly smaller for bomber analysis. Furthermore, this included retrospectively collected post-hoc informations and the possibility of increased intracranial force per unit area within the albumen group might be a confounder. The mortality rates were indistinguishable to the old epidemiological surveies on patients with traumatic encephalon hurt and may be merely a coinciding determination. Finally, why the mortality rates should be so affected is ill-defined and it was beyond the range of the survey. Decision: This is a well-designed survey supplying adequate grounds about the high quality of saline fluid resuscitation over albumen in patients with TBI, but surely no adequate grounds to back up that this the instance in other patient groups in the critical attention unit.As mentioned above this survey was non designed ab initio to look at this subgroup and the population is comparatively little but the consequence is surely deserving farther research. The other inquiries as why albumin fluid does ensue in such inauspicious consequence and whether the different group of patient will act and respond in same manner will originate farther argument and treatment non merely in Clinical pattern but besides on academic base. Harmonizing to CEBM hierarchy of grounds will be Level 2. Subheadings Colloids and crystalloids ; does it count to the Kidney?
Sunday, September 15, 2019
Plato’s Concept of the Ideals
Plato’s concept of the ideals Plato believed that reality is more than what we sense around the world (e. g. taste, smell, hear, see and touch), he believed that behind these physical realities lies a perfect version of them in which he called Forms and that the greatest thing we can learn is to have knowledge and understanding of them. Plato’s theory means that what we can sense around us (for example a chair) is just a mere shadow of the perfect version which exists in the world of Forms. The perfect version of a chair is one in which for fills its purpose e. . to be comfortable and to be sat on. Plato believed that everything had a perfect Form, from objects such as pens and books to things such as beauty and justice. He believed that to experience the world of Forms we had to become perfect philosophers. Plato introduced the ‘Analogy of the cave’ to try and illustrate that human being live and only understand a realm of shadows. Within this explanation Plato used many objects as symbols or metaphors to describe the true meaning of forms, for example, the sun is seen as the Form of Good.Plato describes the world of Forms as ‘unchanging’ in the fact that everything that has yet to be invented in the world of senses already exists in the world of Forms as its perfect version. Plato also believes that that quality’s, such as truth, beauty and justice, all have a universal existence, a reality of their own and Plato believes that we have an innate knowledge of their true Forms. They act ad s cause, source, or necessary, a primary condition for the existence of secondary objects (such as chairs) and actions in the world. To what extent is it true to say that the Forms teach us nothing about the real world?
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